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Recent studies have reported promising findings about the potential therapeutic effects of ALA in NDs, which are summarized in Table 1

In an initial study with researchers using genome-wide CRISPRCas9 suppressor screening, genes involved in peroxisome biogenesis, such as peroxisomal biogenesis factor 10 ( PEX10 ) and peroxisomal biogenesis factor 3 ( PEX3 ), as well as those encoding peroxisomal enzymes, such as alkylglycerone phosphate synthase ( AGPS ) and fatty acyl-CoA reductase 1 ( FAR1 ), were identified (Fig

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Iron that is not bound in a redox-inert form is capable of generating highly deleterious reactive oxygen species (ROS) via a reaction known as the Fenton reaction