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GLR3.3/GLR3 have been implicated in plant defense against herbivores and hormone signaling (Toyota et al, 2018

The side chains of coactivator aromatic residues F+1, L+4, and F+5 insert into the hydrophobic cofactor binding groove on the LBD surface formed by helices 3, 4, and 12 (Figure 3D, left and middle panel)

2020 doi: 10.3390/nano10020235
