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In this model, the reduced anti-tumor immunity of sleep-deprived animals was also indexed by the reduced number of antigen-presenting cells (dendritic cells) in the lymph nodes, as well as by the decreased effector CD4 T-cell numbers and corresponding cytokine profile (decreased IFN-), resulting in lowered Th1 response of Th cells, i.e., the most effective immune response against tumors

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10), revealing a significant decrease in the proportion of F4/80 + iNOS + M1 cells from 64.5% to 30.1%, 29.8%, and 18.9% following treatment with Mn@mHSA, P-Mn@mHSA, and P-Mn/TI@mHSA, respectively