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Several mechanisms have been proposed to explain chronic hyperglycemia-induced nerve damage, such as intracellular accumulation of sorbitol, glycation reactions, and oxidative and nitrosative stress (reviewed in 69)

Schulz G, Schirmer RH, Sachsenheimer W, et al

doi: 10.1016/j.brainres.2005.04.004

10.1182/blood-2011-02-338269 Blood 12 BlissT
