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Description
Clin Exp Med 25(1):72
Injecting too deep (intramuscular) accelerates absorption beyond the intended pharmacokinetic profile and increases the risk of hitting a blood vessel
The dosing schedule follows a careful titration pattern: 2.5mg for the first four weeks, then 5mg, then increases of 2.5mg every four weeks as tolerated up to a maximum of 15mg weekly
In relation to this conclusion it should be noted that the E/I imbalance towards greater inhibition is contrary to the current understanding of schizophrenia
