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Importantly, multiple myeloma is a malignancy where programmed cell death protein 1 (PD-1) and its ligand (PD-L1), is critical for immune evasion and tumor progression (79)

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Anecdotal evidence suggests significant changes in body composition become apparent within this timeframe
Mitochondrial dysfunction, a key feature of AD, further exacerbates ROS production, impairs ATP generation, disrupts calcium homeostasis, and ultimately induces neuronal apoptosis (Bhatt et al., 2021)
