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Also, OS can trigger formation of genotoxic and mutagenic byproducts in the sperm that may increase the risk of disease in the offspring [46]

In addition, dysproteostasis in a wider sense, including disruption of protein degradation pathways such as the UPS and the autophagylysosome system, has been considered a separate hallmark of NDDs

Transcriptional targets of the p53 tumor suppressor gene have also been shown to include antioxidant enzymes and the RRM2B genes, which regulate the codification of the ribonucleotide reductase subunit, preventing DNA dysfunction in mitochondria
