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Increased reactive oxygen species (ROS), weakened antioxidant defences or unrepaired oxidative damage can all be the cause

Dey BR, Furlanetto RW, Nissley P

Intriguingly, two potential targets whose inactivation may elicit ferroptosis, namely xCT and GPx4, are well documented to be modulated by Nrf2

The peptide's intrinsic gastric stability and proline-rich sequence make it more resistant to enzymatic degradation than most peptides, but standard refrigerated storage is still required
