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In light of the highly favorable safety and efficacy profile of metformin as an insulin-sensitizing agent, we certainly recommend against discontinuing this drug in patients with newly diagnosed vitamin B12 deficiency
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Anesthesia and Analgesia 2001;92(4):9971005
But they may support your body's own repair mechanisms, reduce the chronic inflammation that drives progression, and slow cartilage degeneration, particularly when started before the joint has reached end-stage disease
