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10.1038/35102186 166 TakahashiY.KondoK.HiroseT.NakagawaH.TsuyuguchiM.HashimotoM.et al

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Over the course of seven years, I experienced thyroid-related symptoms such as cold intolerance (even when living in Southern California!), acid reflux, and extreme fatigue (I needed 12 hours of sleep to function like my usual self), without knowing what was going on within my body

In a parallel-controlled Phase II-III clinical trial, donafenib demonstrated significantly better overall survival than sorafenib, with a median OS of 12.1 months versus 10.3 months, and exhibited superior safety and tolerability profiles [270]
