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However, in advanced HF, persistent AMPK activation has been associated with transcriptional suppression of CPT1, accelerating the decline in FAO capacity and reinforcing metabolic rigidity (Wang et al., 2009)
E2F1 binds the MFN2 promoter and acts cooperatively with Sp1, facilitating mitochondrial fusion while limiting mitophagy
So, Ive been treating it like a retinoid and screening it out as not safe for pregnancy and something to avoid in nursing if youre conservative
