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The most critical factor determining longevity is storage temperature - every 10C increase roughly doubles degradation rate, making freezer storage (-20C) essential for long-term powder storage and refrigeration (2-8C) mandatory for reconstituted peptides

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But several factors work against this natural recovery process, including age (collagen production drops roughly 1% per year after age 20), the amount of weight lost (more than 50 pounds creates significantly more laxity), how long the excess weight was carried, sun damage history, smoking, genetics, and the speed at which the weight came off
