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de Guglielmo G, Kallupi M, Scuppa G, Stopponi S, Demopulos G, Gaitanaris G, Ciccocioppo R (2014) Analgesic tolerance to morphine is regulated by PPAR

SPARC Is a Source of Copper-binding Peptides that Stimulate Angiogenesis
Improved Metabolism: Can enhance metabolic rates without impacting blood sugar levels

Thus, quenching of excess ROS is very necessary to counter their deleterious effects
