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Readouts should triangulate source and compartment by using matrix/IMS-targeted reporters for H 2 O 2 dynamics, peroxiredoxin-3 (Prx3) redox state as a fast sentinel of matrix oxidant load and functional recovery after stress (e.g., respiration, contractility, cell survival) to confirm that interventions restore signallingdamage balance rather than merely lower bulk ROS (Cardozo et al

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J Ethnopharmacol 326:117966 Li S, Takasu C, Lau H, Robles L, Vo K, Farzaneh T, Vaziri ND, Stamos MJ, Ichii H (2020) Dimethyl fumarate alleviates dextran sulfate sodium-induced colitis, through the activation of nrf2-mediated antioxidant and anti-inflammatory pathways