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J Biol Chem 248: 11881195 Datsenko KA, Wanner BL (2000) Onestep inactivation of chromosomal genes in Escherichia coli K12 using PCR products

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Novel therapies have been developed, and results from recent clinical trials indicate that effective reduction of plasma triglycerides by inhibition of apoC-III might be a promising strategy in management of severe hypertriglyceridemia and, more generally, a novel approach to CHD prevention in those with elevated plasma triglyceride