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In the human, UGT activity is extremely low in the fetal period

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When renal tissue or cells undergo ischemic stress, endogenous DAMPs together with intracellular proinflammatory mediators, such as HSP, HMGB1, metabolites, and gene fragments, are largely release, stimulating immune cells to result in inflammatory cascade (91, 92)

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doi: 10.3389/fimmu.2023.1084448 14 LiCGaoQJiangHLiuCDuYLiL

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