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Chemotherapy and radiation therapy can damage intestinal cells, leading to glutamine deficiency

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Curcumin downregulates P-glycoprotein (P-gp) expression, increasing the accumulation of doxorubicin in drug-resistant breast cancer cells, thereby restoring their sensitivity to the drug (Yan et al., 2024)

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SMYD2 and SETD8 are responsible for inhibiting the interaction between p53 and the CDKN1A promoter, while SETD7 can both enhance the stability of p53 and trigger programmed cell death, and G9a/GLP contributes to the suppression of p53 [87,88,89,90]

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