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Instructions for sample collection and handling are as follows: When it is necessary to perform cytoreductive therapy with the use of corticosteroids or chemotherapy, it is recommended that material first be collected by incisional biopsy, considering that cytoreductive protocols can change the assessment of the cell proliferation index (mitotic count and immunohistochemical analysis for Ki67), and when possible, the excised formation should be reassessed

Disposal of unused or expired medication should follow appropriate pharmaceutical waste disposal guidelines

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