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Larger clinical trials and long-term follow-up studies undertaken to demonstrate the efficacy of this compound in the prevention of cancer have demonstrated an increased incidence of cardiovascular events, which prompted voluntary withdrawal of rofecoxib by the manufacturer in 2004 (see more detailed discussion later)

Mihiel offensive, and later during the operations in the Woevre, Lieutenant Colonel Stilwell displayed military attainments of a high order

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Many mammals evolved smaller body sizes as an adaptation to ecological stresses, such as food scarcity, enabling faster reproduction that promoted species survival and evolution