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The microbial metabolism of AC plays a key role in its pharmacological effects

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Ectopic endometrial tissue exhibits increased local estradiol production due to upregulated aromatase and steroidogenic acute regulatory protein, with decreased 17-hydroxysteroid dehydrogenase 2, leading to enhanced estrogen receptor (ER) activity that promotes lesion survival and proliferation [1,5,6,7]

Teichert, M
