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Niu X, Zhao J, Ma J, Xie C, Edwards H, Wang G, et al

When intravascular hemolysis is very intense and exceeds the capacity of the kidney tubular cells to fixate, hemoglobin, already degraded to methemalbumin and other compounds, is eliminated in the urine (hemoglobinuria), which, as a result, acquires a dark color very characteristic and similar to that of Coca-Cola. When intravascular lysis of erythrocytes occurs, hemoglobin is withdrawn from the circulation by various mechanisms: The first option is to use circulating haptoglobin with the formation of the haptoglobin-hemoglobin complex

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