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Chemotherapy-Induced Cognitive Impairment Is Associated with Cytokine Dysregulation and Disruptions in Neuroplasticity

The truncation dramatically reduces binding to IGF binding proteins (IGFBPs), increases receptor affinity, and shortens half-lifecreating a potent, rapidly-acting growth factor with predominantly local rather than systemic effects when administered

Similar to free Fe 3+ -driven H 2 S production (Fig
