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RA Mechanistic model and clinical evidence of RA The core pathological features of RA include chronic synovial inflammation, abnormal proliferation and enhanced invasiveness of RA synovial fibroblasts (RA-FLS), and eventual destruction of articular cartilage and bone (Fig

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This potent antioxidant acts as the defense line to fight against free radicals and other DNA-affecting compounds present in pollutants, overexposure to sun rays, and smoking habits

[5] Kwon DR, Park GY