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In a type 1 diabetic Akita mouse model, which was used as a nonobese insulin-dependent model of spontaneous type 1 diabetes, empagliflozin treatment attenuated diabetes-induced rise in renal expression of markers of kidney growth by reducing the cyclin-dependent kinase inhibitors p27 and p21, which were over-expressed in early diabetic kidneys (152)

IL1RAP was found to be highly expressed in ES and important for promoting resistance to anoikis , detachment-induced cell death, and metastasis ( 5 Bone microenvironment and metastasis 5.1 Metabolism in the bone tumor microenvironment The function of non-malignant cells in mesenchymal tumors has been less studied when compared to epithelial cancers of adulthood (102, 103), and a mineralized extracellular matrix (ECM) (104)

10.1124/jpet.103.057984 44 RadkZ.TakahashiR.KumiyamaA.NakamotoH.OhnoH.OokawaraT.et al (2002)

MA: Validation, Investigation, Data curation, Conceptualization, Writing review & editing, Writing original draft, Resources, Visualization