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Description
Here, we found that the neuronal conditional-knockout (KO) of glutamyl-cysteine-ligase catalytic-subunit (GCLC), a rate-limiting enzyme for glutathione synthesis, induced brain atrophy accompanied by neuronal loss and neuroinflammation
Initial Treatment: For severe cases, doses can be 1000 mcg to 2000 mcg
The NICE guidelines on obesity management do not include B12 supplementation as a therapeutic option for weight reduction in the absence of documented deficiency
10.1038/nrm3151 Nat
