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through the mechanisms of mechanotransduction, it robustly activates the mTORC1 signaling pathway, facilitates MPS, and enhances neuromuscular functionoutcomes that, when synergistically combined with enhanced local perfusion, mitigate the effects of sarcopenic atrophy (76, 77)

n = 15) and were assessed at 4 and 12 weeks for isometric leg strength, functional performance, body composition, diet, quality of life, and depressive symptoms

MRI revealed symmetrical white matter lesions in the corticospinal tract (Wolters et al., 1982), while diffusion tensor imaging highlighted impaired white matter connectivity due to myelin damage rather than axonal injury ( Heroin also induces psychiatric symptoms, such as depression, anxiety, impulsiveness, and interpersonal sensitivity (Pasternak, 2012)

Of these, 794 were excluded after abstracts screening and identified articles in languages other than English, lack of full text or being review articles, case reports, animal or in-vitro studies