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Description
The decreased activity of the ALDH2 2*2 variant stems from a single amino acid substitution, where lysine replaces glutamate, resulting in a 200-fold increase in the KM (which represents the affinity of an enzyme for its substrate) for NAD+ binding
Novel insights: dynamic foam cells derived from the macrophage in atherosclerosis
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doi: 10.1007/s11011-018-0240-4 143
