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Quantification of CD45 immunolabeling in Figure 2B is provided in Supplementary Figure 2B

For a much deeper insight on the topic, the reader is advised to Pearson and Wienkers Handbook of Drug Metabolism (currently in its 3 edition by CRC Press), Nassars Drug Metabolism Handbook (Wiley and Sons, 2009) and the extensive and unbelievably comprehensive series of articles by Testa and Krmer, many of which have been included in the reference list of the present chapter Editor information Editors and Affiliations Rights and permissions Copyright information 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG About this chapter Cite this chapter Talevi, A., Bellera, C.L

The danger model was first suggested in 1994, were it was first postulated that the immune system responds to substances that cause damage, rather than to those that are simply foreign (93, 94)

however, XKR8 neutrophil-specific KO mice manifested increased susceptibility to fungal infection, as evidenced by higher fungal burdens and more severe lung injury (Fig