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35 In light of these properties, we hypothesize that N-acetylcysteine plays a role in the treatment of COVID-19 infection by the following postulated mechanisms of action (Figure 1): Envelope (E) and spike (S) proteins have a triple cysteine structural motif located directly after the E proteins transmembrane domain (NH 2 - L-Cys-A-Y-Cys-Cys-N -COOH) and a similar motif located in the carboxy terminus of the S protein (NH 2 - S-Cys-G-S-Cys-Cys-K -COOH)

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