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Indeed, loss of function due to mislocalization of TDP-43 causes aberrant cryptic splicing in genes including STMN2 and UNC13A that drive the progression of ALS[1215, 17]

References Shrivastava S, Conigliaro RL

On his blog, Connected Care, patient testimonials include some compelling stories about how the use of subcutaneous methotrexate had changed their lives

Fouad et al
