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Zinc, which is essential for the formation of myelin and can induce oxidative stress in its own right, may be involved in the abnormal homeostasis of bioactive metals, which might play a role in Alzheimer's disease - zinc binds to amyloid precursor protein 57 and aluminium, zinc, iron, and copper directly bind to amyloid protein promoting its aggregation

Phenobarbital 296 Patients 1 Prospective Trial [1] One prospective RCT with phenobarbital 10mg/kg vs placebo (+symptom-triggered lorazepam for both groups) showed significant decrease in both ICU admission rate and continuous lorazepam infusion use (1 single center trial, results have not been duplicated) 1 Retrospective Trial [2] Propofol 225 Patients 5 Retrospective Trials [3 7] 1 Case Series [8] 3 Case Reports [9 11] Dexmedetomidine 6 Retrospective Trials [6 7

[DOI] [PMC free article] [PubMed] [Google Scholar] Chaudhari A, Gupta R, Makwana K, and Kondratov R (2017)

Phytomedicine 102:154193