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In a clinical trial sacubitril/valsartan was shown to be an effective treatment for heart failure with reduced ejection fraction and side effects comparable to the ACE inhibitor enalapril (113)

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Synthetic lethality by targeting glutathione and pyrimidylate kinases in human CML-BC cell lines Finally, we further used several human blast-crisis CML cell lines, including K562, KOPM28, and TCCS, to verify the relationship between ATF4, GSH, and replication stress

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