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Methods: This article is a Systematic Review that synthesizes recent multi-omics and clinical evidence on mechanisms (hormonal, immune-inflammatory, oxidative stress/ferroptosis, genetic/epigenetic, microbiome/metabolic) and appraises therapeutic strategies spanning surgery, hormonal suppression, assisted reproductive technologies (ART), and emerging adjuncts

463 Recently, a research identified that in human corneal epithelial cells exposed to hyperosmotic stress, mtDNA passed through the mPTP pore and was released to the cytoplasm, which activates the cGAS-STING pathway and aggravates inflammation

PMID 1885604

IV treatments may be booked and performed on the same day as assessment if the treatment is warranted and time permits