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Depletion of GSH and therapeutic implications The depletion of GSH levels has been demonstrated in aging and multiple chronic degenerative diseases, including neurodegenerative, cardiovascular, pulmonary, immune disorders and cancers (24, 25)

Antibiotics 11, 951

The downregulation of ChaC2 tends to decrease the levels of glutathione and blocks the self-renewal of these cells

Although microbial-based interventions, such as probiotics, demonstrate therapeutic potentialfor instance, certain strains of Lactobacillus and Bifidobacterium have shown preliminary efficacy in alleviating depressive symptoms (281)their benefits in schizophrenia remain inconsistent and lack high-quality clinical support (282)