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Epigenetic modifications, such as DNA methylation and histone acetylation, may be influenced by environmental factors like diet and physical activity, further modulating metabolic outcomes (Ray et al., 2024)

It also helps lower the stress hormone levels and a faster drop in the diurnal trend

In addition, second-line treatments such as GnRH agonists effectively reduce pain but are compromised by significant menopausal side effects and challenges with long-term tolerability, which has prompted the development of novel oral GnRH antagonists like elagolix, linzagolix, and relugolix that offer dose-dependent estrogen suppression and rapid reversibility

These effects typically resolve within days as the body adjusts