mitochondrial glutathione depletion Frontiers Mitochondrial glutathione depletion reveals a

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The oxidation of Met253 on the latency-associated peptide (LAP-) disrupts its interaction with TGF-1, leading to the activation of latent TGF-1 ligands

Western blot analysis showed that in inflammatory colonic epithelial cells, the expression of ferroptosis-driving molecules (ACSL4 and LPCAT3) was upregulated, while the expression of ferroptosis-protective molecules (GPX4, SLC7A11, and TXNRD1) was downregulated