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Keywords: iron, copper, manganese, zinc, oxidative stress, human diseases Iron Iron is the 26 th element in the periodic table

Experimental work demonstrates that NGF upregulates leukocyte adhesion pathways and facilitates monocyteendothelium interactions while skewing macrophage phenotype, providing a plausible route to TAM accumulation and function in OS (4850)

A detection limit of 5 pg mL 1 (S/N = 3) was observed with a linear range comprised between 10 pg mL 1 and 500 ng mL 1 ( R 2 = 0.993) (Ming et al., 2019)

Then collected serum samples were maintained at20C and used for the investigation of the innate immunity responses