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Atg7 -deficient microglia fail to sustain the DAM signature (downregulating Clec7a , Trem2 , and Tyrobp ) and instead adopt a senescence-associated microglial (SAM) phenotype

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Its mechanism of action targeting stored fat without significantly affecting blood sugar or lean muscle makes it stand out from traditional fat burners and stimulants

Phenotypic screening results are more attractive for this kind of disease, since it only requires the monitoring of some specific biological functions after compounds administration (Khurana et al., 2015)