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Face / trigeminal nerve (especially the ophthalmic V1 branch): pain, burning, or shocks on one side of the forehead/eye/upper face

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High homocysteine levels can also be caused by low vitamin B12 levels because vitamin B12 is the cofactor needed by the enzyme responsible for converting homocysteine to methionine

A common variant in methionine synthase reductase combined with low cobalamin (vitamin B 12) increases risk for spina bifida
