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Chronic low back pain lasting more than six months persistent, ongoing pain that has significantly impacted quality of life Failed conservative care for at least six months inadequate relief from treatments like physical therapy, medications, chiropractic care, or epidural injections MRI evidence of Type 1 or Type 2 Modic changes specific findings showing inflammation or degenerative changes in vertebral endplates, the smoking gun proving vertebrogenic pain Vertebral endplate damage accompanying Modic changes As stated by the manufacturer, the Intracept Intraosseous Nerve Ablation System is intended to be used in conjunction with radiofrequency (RF) generators for the ablation of basivertebral nerves of the L3 through S1 vertebrae for the relief of chronic low back pain of at least six months duration

One of the mechanisms by which senescent cells escape from the immune response is made through the overexpression of the histocompatibility antigen alpha chain E (HLA-E) that bind to NKG2A, an inhibitor receptor expressed on Natural Killer cells (NK) 54 and CD8 + T cells, leading to the inhibition of SnCs recognition