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Hyperglycemia inhibits hepatic production of Sex Hormone Binding Globulin (SHBG), which leads to an increase of free androgens in the blood circulation, and insulin resistance increases the production of androgens by the theca cells
The compound produced measurable weight loss, but not enough to meet the regulatory bar for an obesity drug which requires clinically meaningful weight reduction (typically 5%+ of body weight)
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Studies on the living cornea in vitro
