glutathione synthesis and cysteine Biochemistry | Glutathione Enzymes Cysteine is the substrate for
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In addition, under certain conditions, thioredoxin can promote the conversion of oxidized glutathione to reduced glutathione (Shi et al., 2010)
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Al-Joufi F
Consequently, inhibition of TXN, TrxR and NADPH can lead to inhibited glutathione uptake, reduced GPX4 levels, increased levels of peroxides and oxidised proteins, and ultimately to iron-mediated cell death
