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doi: 10.1016/j.cbpa.2012.04.025
A Review of Bioinformatics Tools to Understand Acetaminophen-Alcohol Interaction
Following intramuscular injection, aripiprazole lauroxil is likely converted by enzyme-mediated hydrolysis to N-hydroxymethyl aripiprazole, which is then hydrolyzed to aripiprazole
This selectivity limitation may be especially relevant for repurposing inhibitors of other proteases for 3CL protease or applying compounds with covalent warheads designed to target cysteine proteases
