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The preservation of proteostasis plays a crucial role in cell survival and becomes even more important for nondividing cells such as neurons, whose proteostasis machineries are reduced with aging, causing an accumulation of damaged organelles and misfolded proteins (327329)
More generally, the ability to transport exogenous natural products is likely to be selected for when these confer fitness benefits on the host (205) , and this probably underpins the finding that successful, marketed drugs are indeed similar to (mainly secondary) natural products (203)
Age dependent changes of tumor cell kinetics
