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What they found: Melanotan II is 100 to 1000 more potent than native -MSH in melanocyte assays Cyclization preserves the active conformation longer than linear -MSH Activates all four functional melanocortin receptors (MC1R, MC3R, MC4R, MC5R) In vivo: visible pigmentation of lizard skin within hours, not days as with -MSH Why it matters: This is the foundational publication of Melanotan II

Competing interests: The authors declare that they have no competing interests

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La acetil L-carnitina (ALC) es una forma modificada de la L-carnitina que se caracteriza por tener mayor biodisponibilidad a nivel cerebral, ya que puede atravesar con ms facilidad la barrera hematoenceflica