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The primary antibodies utilized in this study included DNA/RNA Damage (1:200 dilution, ab62623, Abcam, America), p-ATM (1:50 dilution, R380751, ZEN-BIOSCIENCE, China), p-ERK (1:50 dilution, R380698, ZEN-BIOSCIENCE, China), 8-oxoguanine (1:50 dilution, 130914, Santa Cruz Biotechnology, America), H2A.X (phospho S139) antibody (1:200 dilution, ab81299, Abcam, America), Paxillin antibody (1:200 dilution, ab32084, Abcam, America), The cytoskeleton was stained with FITC-conjugated phalloidin (1:200 dilution, A12379, Invitrogen, America)

This review discusses the muscle microenvironment's changes contributing to these conditions, recent therapeutic approaches like lifestyle modifications, small molecules, and nutritional interventions, and emerging strategies such as gene editing, stem cell therapy, and gut microbiome modulation

HMGCL-induced -hydroxybutyrate production attenuates hepatocellular carcinoma via DPP4-mediated ferroptosis susceptibility

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