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For example, in Alzheimers disease, increased free iron levels are found in amyloid plaques and neurofibrillary tangles, contributing to oxidative stress and neuronal injury [22, 23]

doi: 10.3390/ijms18102173 100

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Predicting outcomes from the phenotype and severity of clinical presentation can be challenging 36,37 , but can be aided by expanding the use of clinical, haemodynamic, imaging, biochemical, immunological and genetic biomarkers 38,39,40,41,42,43,44