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10.1016/j.plefa.2020.102236 47

Carnitine-mediated inhibition of histone deacetylase 3 may boost PGC1 transcription [41] which is a crucial coactivator for various transcription factors required for mitochondrial biogenesis such as NRF1 and 2 [42]

Although ED it is not a life-threatening disease, therapeutic management of ED should not be overlooked, since ED may negatively impact on couple relationship and general health, and even moderate improvements of vascular dysfunction might have a significant clinical impact