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By spectrometry and biochemical analyses, studies further indicated impaired HDL function correlated closely to the alteration in its proteome composition [54, 55, 57], among which changes of apoC3 and apoA5 gained lots of attentions

In more advanced stages, SUM causes nail dystrophy, ridging, partial destruction of the nail plate, ulceration, bleeding, and total destruction of the nail unit (Figure 2)
