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NNMT inhibition or NNMT knockdown significantly increases energy expenditure, reduces body weight and white adipose mass, improves insulin sensitivity, and normalizes glucose tolerance and fasting blood glucose levels

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cAMP binds PKA, causing the regulatory subunits to dissociate from the catalytically active subunits, resulting in increased activity of the enzyme (60)

Over-dilution (too much water) increases oxidative exposure surface area